InkSeine integrates four key concepts: it leverages preexisting ink to initiate a search; it provides tight coupling of search queries with application content; it persists search queries as first class objects that can be commingled with ink notes; and it enables a quick and flexible workflow where the user may freely interleave inking, searching, and gathering content. InkSeine offers these capabilities in an interface that is tailored to the unique demands of pen input, and that maintains the primacy of inking above all other tasks. Source
Words don't do it justice. Here's a short video that captures some of the software's brilliance:
Finally, here's a screen shot of the first page of an InkSeine document I'm using to gather information and thoughts for a new blog post I'm romancing.